Optimal Dose of Plasmid Vascular Endothelial Growth Factor for Enhancement of Angiogenesis in the Rat Brain Ischemia Model
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چکیده
منابع مشابه
Optimal dose of plasmid vascular endothelial growth factor for enhancement of angiogenesis in the rat brain ischemia model.
Vascular endothelial growth factor (VEGF) administration has recently been assessed as a therapeutic strategy for ischemic diseases including brain ischemia because of its angiogenic effect. However, VEGF also causes detrimental adverse effects by increasing vascular permeability. This study examined whether plasmid human VEGF (phVEGF) administration induced angiogenic effects in the rat brain ...
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15 صفحه اولEndothelial Growth Factor Expression in a Rat Hindlimb Ischemia Model Angiogenesis Induced by Endothelial Nitric Oxide Synthase Gene Through Vascular
Tsunetatsu Namba, Hiromi Koike, Kazushi Murakami, Motokuni Aoki, Hirofumi Makino, Endothelial Growth Factor Expression in a Rat Hindlimb Ischemia Model Angiogenesis Induced by Endothelial Nitric Oxide Synthase Gene Through Vascular Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, ...
متن کاملAngiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model.
BACKGROUND Because the mechanism of the angiogenic property of nitric oxide (NO) was not fully understood in vivo, we focused on the role of vascular endothelial growth factor (VEGF) in angiogenesis induced by endothelial NO synthase (eNOS) gene transfer. METHODS AND RESULTS After intramuscular injection of eNOS DNA into a rat ischemic hindlimb, transfection of eNOS vector resulted in a signi...
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ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 2010
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.50.449